Magnesium (Mg) is one of the most important macro-elements responsible for the proper functioning of the body. It provides about 0,05% of body weight of an adult man (24-35 g). Highest magnesium content in the human body is characteristic for bone tissue (around 60%). The remaining part of the pot of this element is refunded in the muscles and other soft tissues (about 20%). In turn, tissue fluids are characterized by the least magnesium content (approx. 1%).
The demand for magnesium in humans depends on both gender and age.
In the adult human being it stands on average 300 mg per day. In pregnant women and nursing mothers, the demand for this element is higher about 50% (450 mg per day). Its correct concentration in blood serum should be 18-30 mg/l (0. 75-1. 25 mmol/l).
The state of the organism, in which there is a decrease in the concentration of magnesium in the blood below 0. 7 mmol/l is called hypomagnesemia. It can contribute to the creation of the following clinical signs:
- increased neuromuscular excitability,
- increase the susceptibility to stress,
- anxiety, depression,
- weakness, fatigue,
- impaired concentration,
- incorrect work of the heart,
- painful cramps in the calves,
- brittle nails,
- night sweats,
- shaky hands and eyelids,
- dilution of libido.
Factors that may affect the formation hypomagnesemia:
- incorrect diet (a diet rich in animal fats, fiber and calcium),
- large amounts of coffee, tea, alcohol,
- weight loss,
- a large amount of phosphates contained in food,
- the use of contraceptives, antibiotics, cytostatics, tranquilizers, psychotropic drugs.
Adequate magnesium content in the human body is extremely important, because of the key role played by the element in the proper functioning of the whole organism.
- Magnesium takes part in the synthesis of nucleic acids, proteins and lipids. In addition, as an activator of many enzymes, plays an important role in the stabilization and transformation of the body.
- In the skeletal system, magnesium is responsible for proper bone mineralization. It can facilitate the process of absorption of calcium, by increasing the activity of vitamin D3. Some studies suggest that magnesium deficiency may be an additional risk factor for the development of postmenopausal osteoporosis. A possible reason for this fact is the effect of magnesium deficiency on the activity of hormones that regulate the calcium management in the body. It was reported also that the magnesium increases calcium absorption from the intestine and strengthens the mechanical properties of bone, which is important in the context of the prevention of osteoporosis.
- Together with calcium, magnesium is responsible for normal muscle work, both the skeletal and heart muscle. In addition, by relaxing the smooth muscles in blood vessels, magnesium helps to reduce blood pressure.
- In the nervous system it affects the proper conduction of nerve impulses. By reducing the excitability of nerve cells, counteracts the excessive release of neurotransmitters.
- In addition, it was observed that magnesium prevents depressive states and neurosis, relieves stress, and brings relief in migraines and tension headaches. Affect mental activity by helping the process of lifelong learning, memorization and concentration.
Magnesium absorption process in the human body mainly takes place in the small intestine (jejunum), to a lesser extent in the large intestine. It occurs simultaneously with the absorption process of water. The factors that favour the absorption of magnesium are:
- a diet rich in animal proteins, unsaturated fats,
- the acidic environment,
- vitamin B6,
- vitamin D,
- insulin secretion.
Magnesium belongs to a group of elements that are hard assimilable, average only 30% of magnesium in the diet is absorbed. Dietary supplements may contain magnesium that occurs both in the form of inorganic and organic salts. Inorganic magnesium salts include: chlorides, sulphates, nitrates, and carbonates, in turn, organic magnesium salts used in dietary supplements are primarily: citrate, ascorbate , aspartate , gluconate and lactate. It should be noted that the far better absorpted are organic salts of magnesium, which includes magnesium citrate used in our preparation. This is due to similar construction of magnesium citrate to magnesium compounds occurring naturally in foods. In addition, research conducted by Walker and colleagues (2003) shows that among the three tested forms of magnesium (citrate, chelate and oxide), magnesium citrate had the best bioavailability within 60 days of application. Therefore, selecting the right preparation with magnesium note both the form in which it occurs and the bioavailability of the element.
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